Metagenomics bears upon all aspects of microbiology, including our understanding of mitochondrial and eukaryote origin. Recently, ribosomal protein phylogenies show the eukaryote host lineage – the archaeal lineage that acquired the mitochondrion – to branch within the archaea. Metagenomic studies are now uncovering new archaeal lineages that branch more closely to the host than any cultivated archaea do. But how do they grow? Carbon and energy metabolism as pieced together from metagenome assemblies of these new archaeal lineages, such as the (...) Deep Sea Archaeal Group (including Lokiarchaeota) and Bathyarchaeota, do not match the physiology of any cultivated microbes. Understanding how these new lineages live in their environment is important, and might hold clues about how mitochondria arose and how the eukaryotic lineage got started. Here we look at these exciting new metagenomic studies, what they say about archaeal physiology in modern environments, how they impact views on host‐mitochondrion physiological interactions at eukaryote origin. (shrink)

Consumers of software often face an acquisition-mode decision, namely whether to purchase or pirate that software. In terms of consumer welfare, consumers who pirate software may stand in opposition to those who purchase it. Marketers also face a decision whether to attempt to thwart that piracy or to ignore, if not encourage it as an aid to their software's diffusion, and policymakers face the decision whether to adopt interventionist policies, which are government-centric, or laissez faire policies, which are marketer-centric. Here (...) in order to assess the decision-making of all three of these stakeholders, we focus on the consumer's point-of-view as central and examine it by considering on a comparative basis the ethical dimension versus other dimensions, including economic, legal, and other salient consumer behavior considerations. Based on a survey of 689 software consumers conducted over the Internet, the results indicate that ethics as a factor is embedded in a multidimensional set of determinant factors influencing software piracy, including attitudes, legal aspects, social support, perceptions of economic loss and age. Policy and research implications, based on these findings, are provided. (shrink)

Consumers of software often face an acquisition-mode decision, namely whether to purchase or pirate that software. In terms of consumer welfare, consumers who pirate software may stand in opposition to those who purchase it. Marketers also face a decision whether to attempt to thwart that piracy or to ignore, if not encourage it as an aid to their softwares diffusion, and policymakers face the decision whether to adopt interventionist policies, which are government-centric, or laissez faire policies, which are marketer-centric. Here (...) in order to assess the decision-making of all three of these stakeholders, we focus on the consumers point-of-view as central and examine it by considering on a comparative basis the ethical dimension versus other dimensions, including economic, legal, and other salient consumer behavior considerations. Based on a survey of 689 software consumers conducted over the Internet, the results indicate that ethics as a factor is embedded in a multidimensional set of determinant factors influencing software piracy, including attitudes, legal aspects, social support, perceptions of economic loss and age. Policy and research implications, based on these findings, are provided. (shrink)

This paper uses themes from Catholic social teaching to challenge Church and society to prioritize a group that is left behind by social injustice: people with intellectual disabilities. It provides background information on intellectual disability, summarizes moral principles of Catholic social doctrine, describes sociological facts about how people with intellectual disabilities are left behind by social factors, and prescribes actionable solutions for treating them as equal members of society. The goal is to identify how to shape a society at all (...) socio-ecological levels in ways that better protect the dignity, solidarity, and participation of people with intellectual disabilities. Although the analysis references the US and is limited to intellectual disabilities, its lessons apply to other countries and disabilities as well. (shrink)

In this article, we present results from a literature review of intrinsic, instrumental, and relational values of nature conducted for the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, as part of the Methodological Assessment of the Diverse Values and Valuations of Nature. We identify the most frequently recurring meanings in the heterogeneous use of different value types and their association with worldviews and other key concepts. From frequent uses, we determine a core meaning for each value type, which is (...) sufficiently inclusive to serve as an umbrella over different understandings in the literature and specific enough to help highlight its difference from the other types of values. Finally, we discuss convergences, overlapping areas, and fuzzy boundaries between different value types to facilitate dialogue, reduce misunderstandings, and improve the methods for valuation of nature's contributions to people, including ecosystem services, to inform policy and direct future research. © 2023 The Author(s). Published by Oxford University Press on behalf of the American Institute of Biological Sciences. (shrink)

Neurodevelopmental disorders (NDDs), such as autism and ADHD, are behaviorally defined adaptive functioning difficulties arising from variations, alterations and atypical maturation of the brain. While it is widely agreed that NDDs are complex conditions with their presentation and functional impact underpinned by diverse genetic and environmental factors, contemporary and polarizing debate has focused on the appropriateness of the biomedical as opposed to the neurodiverse paradigm in framing conceptions of these conditions. Despite being largely overlooked by both research and practice, the (...) International Classification of Functioning Disability and Health (ICF) endorsed by the World Health Organization in 2001 views functioning dynamically, offering a framework for investigating, assessing and treating NDDs holistically. Exemplified by autism and ADHD, we argue that the ICF provides not only a multitude of opportunities in accounting for the environmental determinants in researching and clinically managing NDDs, but opportunities for harmonizing the seemingly irreconcilable biomedical and neurodiverse paradigms. Also see the video abstract here: https://youtu.be/YwuWPDUOs5k. (shrink)

A key question in disability studies, philosophy, and bioethics concerns the relationship between disability and well-being. The mere difference view, endorsed by Elizabeth Barnes, claims that physical and sensory disabilities by themselves do not make a person worse off overall—any negative impacts on welfare are due to social injustice. This article argues that Barnes’s Value Neutral Model does not extend to intellectual disability. Intellectual disability is (1) intrinsically bad—by itself it makes a person worse off, apart from a non-accommodating environment; (...) (2) universally bad—it lowers quality of life for every intellectually disabled person; and (3) globally bad—it reduces a person’s overall well-being. While people with intellectual disabilities are functionally disadvantaged, this does not imply that they are morally inferior—lower quality of life does not mean lesser moral status. No clinical implications concerning disability-based selective abortion, denial of life-saving treatment, or rationing of scarce resources follow from the claim that intellectual disability is bad difference. (shrink)

Research shows that a high majority of parents receiving prenatal diagnosis of intellectual disability terminate pregnancy. They have reasons for rejecting a child with intellectual disabilities—these reasons are, most commonly, beliefs about quality of life for it or them. Without a negative evaluation of intellectual disability, their choice makes no sense. Disability-based abortion has been critiqued through virtue ethics for being inconsistent with admirable moral character. Parental selectivity conflicts with the virtue of acceptingness and exhibits the vice of wilfulness. In (...) this paper I claim that, beyond failures of moral virtue, disability abortion often involves failures of epistemic virtue on the part of parents. I argue two things: parents believe something false, or at least contested, about life with intellectual disability—and they do so because they are not epistemically conscientious. I first explain why a central motivation for disability abortion—that it prevents harm to the child—is mistaken. I next give a brief account of intellectual virtue and culpable ignorance. I then indicate why many parents fail to be intellectually virtuous when choosing to terminate pregnancy. I focus on elimination of intellectual disability and have little to say about physical and sensory impairments. (shrink)

In this paper I argue that selective abortion for disability often involves inadequate counselling on the part of reproductive medicine professionals who advise prospective parents. I claim that prenatal disability clinicians often fail in intellectual duty—they are culpably ignorant about intellectual disability. First, I explain why a standard motivation for selective abortion is flawed. Second, I summarize recent research on parent experience with prenatal professionals. Third, I outline the notions of epistemic excellence and deficiency. Fourth, I defend culpable ignorance as (...) the best explanation of inadequate disability counselling. Fifth, I rebut alternative explanations. My focus is pregnancies diagnosed with mild or moderate intellectual disability. (shrink)

Humans’ indigenous microbes strongly influence organ functions in an age‐ and diet‐dependent manner, adding an important dimension to aging biology that remains poorly understood. Although age‐related differences in the gut microbiota composition correlate with age‐related loss of organ function and diseases, including inflammation and frailty, variation exists among the elderly, especially centenarians and people living in areas of extreme longevity. Studies using short‐lived as well as nonsenescent model organisms provide surprising functional insights into factors affecting aging and implicate attenuating effects (...) of microbes as well as a crucial role for certain transcription factors like forkhead box O. The unexpected beneficial effects of microbes on aged animals imply an even more complex interplay between the gut microbiome and the host. The microbiome constitutes the major interface between humans and the environment, is influenced by biosocial stressors and behaviors, and mediates effects on health and aging processes, while being moderated by sex and developmental stages. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The Covid-19 pandemic provides a real-world context for evaluating the fairness of disability-based rationing of scarce medical resources. I discuss three situations clinicians may face: rationing based on disability itself; rationing based on inevitable disability-related comorbidities; and rationing based on preventable disability-related comorbidities. I defend three conclusions. First, in a just distribution, extraneous factors do not influence a person’s share. This rules out rationing based on disability alone, where no comorbidities decrease a person’s capacity to benefit from treatment. Second, in (...) a just distribution, undeserved luck does not influence a person’s share. This rules out rationing for biologically caused comorbidities that decrease capacity to benefit. Third, in a just distribution, social injustice does not influence a person’s share. This rules out rationing for socially caused comorbidities that decrease capacity to benefit. (shrink)

The traditional elimination view affirms that people with intellectual disabilities will be healed in heaven when God restores all things to what they were meant to be. Several contemporary scholars, however, have put forth a revisionist retention view claiming that people with intellectual disabilities will not be healed in heaven. While the elimination view has strong biblical and theological credentials, it faces a significant philosophical difficulty. Heaven must maintain identity so that individuals exist as the same people they were in (...) life. But post-mortem healing appears to disrupt the identity of people with intellectual disabilities. In this paper I reject this charge. I argue that for individuals with mild or moderate intellectual disabilities heaven preserves personal identity, while for individuals with profound intellectual disabilities heaven creates personal identity. These conclusions rest on an emergentist anthropology which I describe. (shrink)

While there are many significant ethical questions which can deliver the lessons of an introductory ethics course (e.g. global warming, world hunger, genetic engineering), students do not face these moral difficulties directly in their lives. The author argues that commonly-faced ethical questions are more effective for rendering the content of introductory ethics immediately relevant to students. This paper presents a general outline of an introductory ethics course structured around the theme of drunk driving. Not only is drunk driving something that (...) college students are confronted with consistently, but the topic lends itself to discussions of moral subjectivism and moral skepticism, various moral theories’ framings of the problem, the assignment of culpability and conditions which mitigate it, secondary responsibility, intoxication and agency, punishment, deterrents, contrition, and forgiveness. The author details each of these discussions and concludes by considering further benefits of teaching a course built around this theme. (shrink)

While there are many significant ethical questions which can deliver the lessons of an introductory ethics course (e.g. global warming, world hunger, genetic engineering), students do not face these moral difficulties directly in their lives. The author argues that commonly-faced ethical questions are more effective for rendering the content of introductory ethics immediately relevant to students. This paper presents a general outline of an introductory ethics course structured around the theme of drunk driving. Not only is drunk driving something that (...) college students are confronted with consistently, but the topic lends itself to discussions of moral subjectivism and moral skepticism, various moral theories’ framings of the problem, the assignment of culpability and conditions which mitigate it, secondary responsibility, intoxication and agency, punishment, deterrents, contrition, and forgiveness. The author details each of these discussions and concludes by considering further benefits of teaching a course built around this theme. (shrink)

The theology of Dietrich Bonhoeffer, which is deeply rooted in classical Christology and Lutheran orthodoxy, has close affinities with views about the nature of God and God’s relationship with the world that has recently been labeled “open theism.” Bonhoeffer’s concepts of God, freedom, providence and ethics provide relational views of God with firm theological credentials and exemplify a strong integration of philosophy and theology.

Too often, ethics courses are taught in a way that Aristotle would reject, viz., they aim at the acquisition of theoretical moral knowledge as an end in itself. Aristotle instead argued that the ultimate goal in studying ethics should be to become good. This paper proposes a way to teach introductory ethics that takes Aristotle’s goal seriously. Such a course emphasizes the study of applied virtue ethics by exploring the nature of many of the most dangerous vices (e.g., envy, greed, (...) and lust) and detailing various concepts involved in, and ways individuals respond to, their own moral shortcomings, e.g., making excuses, repenting, the nature of temptation and forgiveness. Such a course, it is argued, can both convey many important points in ethical theory and moral reasoning as well as bridge the gap between abstract knowledge of an ethical theory and ethical choices that students face in their daily lives. (shrink)

This paper argues that to study and teach ethics without due attention to feminism and other relevant aspects of critical theory (e.g. race or sexual orientation) is to be ethically handicapped. In arguing for this point, the author explains the key components of critical theory, how critical theory augments critical thinking insofar as the former points out certain limitations of exclusive abstract analysis, and how a consideration of critical theory can aid teachers to achieve their learning objectives. In illustrating these (...) points, the paper points to various perspectives on the nature and scope of sexual harassment. (shrink)

In this paper I defend three points: (1) God loves and desires the salvation of every human person, (2) saving grace is available outside of the Christian church to those who do not hear the gospel but pursue moral goodness and (3) most, if not all, human persons will be saved. I argue that soteriological restrictivism is logically incoherent since its two ideas—every person is loved by God and only those who hear and believe the Christian gospel can be saved—cannot (...) both be true. Throughout I integrate insights from Karl Rahner’snotion of “anonymous Christianity.”. (shrink)

There is another element in ancient Greek philosophy which goes in tandem with this effort to give an account of the physical universe and its parts. It is the reaching out for or the attempt to grasp being, reality, or what is. The thought behind this endeavor seems to have been that there exist certain basic entities which it is incumbent upon philosophers to grasp and in terms of which the generation of and the goings-on in the physical universe are (...) to be explained. While this connection between philosophy and the quest for being is more or less overt in a number of the Greek philosophers, one of its most explicit acknowledgements is made by Plato, who in one dialogue has Socrates refer several times to the philosopher’s search for reality and to philosophy itself as a discipline which liberates the soul so that it may contemplate being or reality. (shrink)

This paper reports on a pedagogical strategy used when discussing consensual and non-consensual sex in college ethics courses. The paper outlines a general teaching technique designed to elicit what students already think about a particular issue and then applies this general technique to the seven specific cases involving unwanted sex. Classroom results on these cases are described, reporting that students tend to adopt two different definitions of what it means for sex to be “consensual”. A commentary on these cases is (...) provided that can be used to encourage students to think through the cases critically, and the author provides a brief commentary on how these cases relate to the notion of autonomy. (shrink)

This paper reports on a pedagogical strategy used when discussing consensual and non-consensual sex in college ethics courses. The paper outlines a general teaching technique designed to elicit what students already think about a particular issue and then applies this general technique to the seven specific cases involving unwanted sex. Classroom results on these cases are described, reporting that students tend to adopt two different definitions of what it means for sex to be “consensual”. A commentary on these cases is (...) provided that can be used to encourage students to think through the cases critically, and the author provides a brief commentary on how these cases relate to the notion of autonomy. (shrink)

The mere difference view, endorsed by some philosophers and Christian scholars, claims that disability by itself does not make a person worse off on balance—any negative impacts on overall welfare are due to social injustice. This article defends the bad difference view—some disability is bad not simply because of social arrangements but because of biological deficits that, by themselves, make a person worse off. It argues that the mere difference view contradicts core doctrines of Christian faith. The analysis focuses on (...) intellectual rather than physical or sensory disabilities. (shrink)

The mere difference view, endorsed by some philosophers and Christian scholars, claims that disability by itself does not make a person worse off on balance—any negative impacts on overall welfare are due to social injustice. This article defends the bad difference view—some disability is bad not simply because of social arrangements but because of biological deficits that, by themselves, make a person worse off. It argues that the mere difference view contradicts core doctrines of Christian faith. The analysis focuses on (...) intellectual rather than physical or sensory disabilities. (shrink)

This paper focuses on the benefits of discussing moral issues concerning the domestic realm in an introductory ethics course, especially moral issues surrounding divorce. The subject of divorce in introductory courses can illustrate to students significant dimensions in ethical theory and also serves as a useful pedagogical tool to bridge the gap between abstract ethical theories and students’ daily lives. Divorce is a common experience that allows students to personally engage with ethical questions that often have often immediate relevance to (...) their personal morality. (shrink)

College courses are often disconnected both from other disciplines and from student’s lives. When classes are taught in isolation from each other students experience them as unrelated fragments. In addition, college courses often lack personal meaning and relevance. Interdisciplinary learning communities—classes in which the subject matters of two or more fields are integrated—can help overcome these two problems by providing an education that is holistic and coherent. In this paper I report on how philosophy courses can be blended with English (...) classes and how theoretical perspectives can be connected to student’s personal lives. (shrink)

College courses are often disconnected both from other disciplines and from student’s lives. When classes are taught in isolation from each other students experience them as unrelated fragments. In addition, college courses often lack personal meaning and relevance. Interdisciplinary learning communities—classes in which the subject matters of two or more fields are integrated—can help overcome these two problems by providing an education that is holistic and coherent. In this paper I report on how philosophy courses can be blended with English (...) classes and how theoretical perspectives can be connected to student’s personal lives. (shrink)

Political theory contains two views of social care for people with intellectual disabilities. The favor view treats disability services as an undeserved gratuity, while the entitlement view sees them as a deserved right. This paper argues that David Hume is one philosophical source of the favor view; he bases political membership on a threshold level of mental capacity and shuts out anyone who falls below. Hume’s account, which excludes people with intellectual disabilities from justice owing to their lack of power, (...) but includes them in charity, is morally deficient. The shortcomings of Hume’s theory underscore the necessity of having a view of justice which ensures that people with intellectual disabilities are not marginalized. In defending the entitlement view, I integrate philosophical analysis and concrete examples of policy issues. (shrink)